(A) Schematic of the full-length SARS-CoV-2 S protein primary structure colored by domain: N-terminal domain (NTD, 16–291), receptor binding domain (RBD, 330–530), furin cleavage site (S1/S2), fusion peptide (FP, 817–834), central helix (CH, 987–1034), connecting domain (CD, 1080–1135), heptad repeat 2 (HR2, 1163–1210) domain, transmembrane domain (TM, 1214–1234), and cytoplasmic tail (CT, 1235–1273). Representative icons for N-glycans (blue and green) and O-glycan (yellow) are also depicted according to their position in the sequence.

A Schematic of the full length SARS CoV 2 S protein primary structure colored by domain N terminal domain NTD 16291 receptor binding domain RBD 330530 furin cleavage site S1S2 fusion peptide FP 817834 central helix CH 9871034 connecting domain CD 10801135 heptad repeat 2 HR2 11631210 domain transmembrane domain TM 12141234 and cytoplasmic tail CT 12351273 Representative icons for N glycans blue and green and O glycan yellow are also depicted according to their position in the sequence